Books about Novartis from Amazon.com

Many human diseases arise from the malfunction of signalling components, in particular alterations of multiple components of an integrated signalling network. Experimental and computational tools to describe and quantify these changes are increasingly available, providing a wealth of data that can stimulate systematic analysis of the entire signalling network and enable prediction of disease states not easily recognizable from complex data sets.

This groundbreaking book explores the structural and temporal complexity in biological signalling exemplified in neuronal, immunological, humoral and genetic signal transduction networks. With discussions between experimentalists and theoretically oriented scientists, this book takes an interdisciplinary approach that may help switch the analysis of biological signalling from descriptive to predictive science and capture the behaviour of entire systems.

• Explores the structural and temporal complexity in biological signalling.
• Represents an unusual collocation of three different areas: immunology, cell signalling and neural networks.
• Contains interdisciplinary discussions between experimentalists and theoretically oriented scientists, in particular those working on computer simulations.

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Price: $70.00 [Notify me when price goes down.]

The cerebral cortex is the crowning achievement of evolution and the biological substrate of human mental capacities Using a comparative evolutionary developmental approach to the study of its origin helps to offer new insights into this complex and important problem. The comparison of immature stages reveals features of evolution that are otherwise obstructed by the complexity of the mature brain, and the analysis of development in terms of possible evolutionary events helps us to focus on the most biologically relevant mechanisms. In this book, leading experts in the fields of mammalian, reptilian, avian and amphibian brain development and from evolutionary biology, tackle the fundamental question of the origin of the cerebral cortex. The book includes critical examinations of methods used to study homology in the central nervous system and methods used in cladistic analysis. Recent data on the earliest generated transient cells in the mammalian, reptilian, avian and amphibian forebrain are discussed, as are possible homologies based on specific connectional analysis. The various hypotheses on the origin of the mammalian isocortex are discussed in detail and new results are presented on cortical organization in reptiles, birds, marsupials, monotremes and other species..
Price: $22.94 [Notify me when price goes down.]

The formation of blood vessels is an essential aspect of embryogenesis in vertebrates  It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions.

In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups.

The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues.

The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation.

While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues.

With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome..
Price: $91.75 [Notify me when price goes down.]

This book draws together contributions from some of the leading investigators in the field of autism to consider specific problem areas in current research. Each contributor brings expertise from a different field, providing a balanced view of the whole spectrum of study of this disorder. It covers four main areas:

* Twin and family studies indicate that the heritability of the underlying liability to autism exceeds 90% and point to a multifactorial causation, involving a relatively small number of susceptibility genes. The book discusses this issue in detail, along with the problem of why some additional symptoms are associated with autism while others are not.

* New techniques are available for examining the neurobiology of autism. The book contains results from imaging studies showing the contributions of different brain regions to autism.  It includes neuropathological data and examines the neuropharmacology of autism.

* There is considerable discussion concerning the fundamental psychological deficit in children with autism. There is good evidence that "Theory of Mind" deficits are associated with autism and this issue is discussed in the book, as are other competing possibilities.

* The most important practical question facing medical and psychological practitioners is how to help children with autism. The evidence relating to possible psychological or psychiatric interventions for rehabilitation of children with autism is examined in detail. Drug treatments have generally been disappointing in this field and there is one chapter devoted specifically to this problem.

The book focusses ultimately on intervention studies and so is of practical relevance to people interested in helping autistic children. In addition, it provides a very convenient summary of the principal controversies which currently exist in research on autism..
Price: $112.83 [Notify me when price goes down.]

With the recent renaissance in mitochondrial biology and increasing recognition of their role in many diseases, this book provides a timely summary of the current state-of-the-art in mitochondrial research. The book opens with the regulation of mitochondrial replication and biogenesis and reviews the mechanisms and functional consequences of mitochondrial fission and fusion. Further chapters address mitochondria and oxidative stress and their roles in cell signalling and cell death. The book includes extensive, fascinating discussion of the biochemistry of mitochondrial cell signalling (especially involving calcium) and of oxidative stress. The nature of the proteins engaged in these processes, many only recently discovered, is covered in detail.

Mitochondria have been strongly implicated in neurodegenerative diseases such as Parkinson’s, Huntington’s and amyotrophic lateral sclerosis. They are also affected in cancer, ageing and cardiovascular disease. The final section of the book reviews mitochondrial mutations and their consequences in ageing and other phenotypic manifestations. The authors discuss how mitochondrial proteins might constitute important therapeutic targets and describe initial attempts to develop compounds that can regulate their function..
Price: $126.21 [Notify me when price goes down.]

The veterinary illustrations in this atlas are composites created to most clearly illustrate common orthopedic conditions associated with osteoarthritis As technological innovations continue to revolutionize the practice of veterinary medicine, so too should our educational tools be revolutionalized to create better understanding. Novartis Animal Health US, Inc. is dedicated to providing the veterinary industry with the latest advancements in pharmaceutical products and also the tools and resources that support the practitioner in diagnosis and client education. The illustrations in this reference were captured from three-dimensional graphics created by the professioanl illustrators at Visible Productions. These images were then complemented with radiographs and arthroscopic captures to further elucidate specific conditions. The images printed in the book are only a small sample of the images captured on the accompanying CD. Additionally, the CD also includes images, which can be rotated and dissected by the viewer for an interactive experience..
Price: $32.49 [Notify me when price goes down.]

To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime.  This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system.

Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder..
Price: $96.00 [Notify me when price goes down.]