Books about Toxicogenomics from Amazon.com

Molecular Toxicology is the first volume of a three-volume set Molecular, Clinical and Environmental Toxicology that offers a comprehensive and in-depth response to the increasing importance and abundance of chemicals in daily life. By providing intriguing insights far down to the molecular level, this work covers the entire range of modern toxicology with special emphasis on recent developments and achievements. It is written for students and professionals in medicine, science, public health and engineering who are demanding reliable information on toxic or potentially harmful agents and their adverse effects on the human body.

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Price: $157.99 [Notify me when price goes down.]

Toxicogenomics: A Powerful Tool For Toxicity Testing provides up-to-date state-of-the-art information presented by the recognized experts, and is therefore an authoritative source of current knowledge in this field of research. The potential link between toxicology, genetics and human diseases makes this book very useful to investigators in many and varied disciplines of science and toxicology.

Topics covered include:

• mechanistic toxicogenomics
• analysis and interpretation of toxicogenomic data
• principles of data mining in toxicogenomics
• design issues in toxicogenomics studies
• sources of variability in toxicogenomic assays
• Escherichia coli stress response as a tool for detection of toxicity
• toxicogenomics as a tool to assess immunotoxicity
• toxicogenomics and ecogenomics for studying endocrine disruption and basic biology
• use of toxicogenomics as an early predictive tool for hepatotoxicity
• nutrigenomics: the application of genomic signatures in nutrition-related research
• application of toxicogenomics in drug discovery
• potential uses of toxicogenomic biomarkers in occupational health and risk assessment
• usefulness of toxicogenomics in the regulatory environment
• perspectives on toxicogenomics at the US Environmental Protection Agency

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Price: $140.24 [Notify me when price goes down.]

Toxicogenomics is a new, dynamic and very promising field that can help optimize toxicity analyses and streamline research into active substances It is of interest not only for basic research and development, but also from a legal and ethical perspective. Here, experts from all the fields mentioned will find solid information provided by an international team of experienced authors. With its approach as an interdisciplinary overview, it will prove particularly useful for all those needing to develop appropriate research strategies.

The authors work for major research institutions, such as the Fraunhofer Institute of Toxicology and Experimental Medicine (Germany), the German Cancer Research Center, the National Institute of Environmental Health Science (USA), the National Institute of Health Science (Japan) or for companies like Affymetrix, Altana Pharma, Bayer, Boehringer Ingelheim, Bruker, Merck, Nimblegen, Novartis, and Syngenta. Coverage ranges from the technology platforms applied, including DNA arrays or proteomics, via the bioinformatics tools required, right up to applications of toxicogenomics presented in numerous case studies, while also including an overview of national programs and initiatives as well as regulatory perspectives.

Walter Rosenthal, Director of the Research Institute for Molecular Pharmacology in Berlin, praises the book thus: "I would like to congratulate the publishers of this handbook, one that deals with a extremely hot topic. They have succeeded in gaining as authors leading representatives from this field. The Handbook impressively shows how modern genomic research is leading to rapid advances and new insights within toxicology.".
Price: $133.90 [Notify me when price goes down.]

The availability of new molecular approaches to the selection of drug therapy is an emerging need, as the traditional approach based on the evaluation of patient and tumor characteristics is clearly far from optimal. Many, and in most cases the majority of treated patients do not have significant benefits from the treatment while they often experience moderate to severe toxicities. In “Pharmacogenomics, Anticancer Drug Discovery, and Response”, edited by Federico Innocenti, readers will find a series of chapters addressing the role of genomic information in cancer therapy and in drug development representing a unique source, as it describes experimental approaches, statistical strategies, and clinical examples of the application of genomic medicine in oncology. This book provides the most comprehensive body of knowledge on the role of genetic and genomic variation in the individualization of drug therapies in cancer patients.

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Price: $126.41 [Notify me when price goes down.]

With the sequencing of human and other genomes completed, the new field of toxicogenomics is now emerging into the realm of practice This field brings together many different disciplines to incorporate current genomics knowledge into traditional toxicology. By finding more precise ways to measure the response of living systems and environments to chemical exposures, toxicogenomics promises to greatly alter and improve the drug development process, to name just one area of application.

Toxicogenomics: Principles and Applications provides a unified, thorough text on key breakthrough technologies in genomics, proteomics, metabonomics, and bioinformatics, as well as their applications to toxicology research. Coverage includes:

• A general introduction to toxicology for nonspecialists
• Microarray/high-density gene expression profiling
• Quantitative RNA measurement
• Analysis of metabolites (metabonomics)
• Statistics and databases for toxicogenomics
• Functional genomics models
• Protein analysis and profiling

Throughout Toxicogenomics, the emphasis remains on information practitioners can put to use immediately. Numerous illustrations support the text, and a helpful summary lists key software and Internet tools, as well as additional resources. Written for specialists and nonspecialists alike, Toxicogenomics gives a wide range of researchers access to the unique combination of disciplines that characterize this exciting new field..
Price: $64.54 [Notify me when price goes down.]

This digital document is an article from Environmental Health Perspectives, published by National Institute of Environmental Health Sciences on July 1, 2005. The length of the article is 5861 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: Ushering in the new toxicology: toxicogenomics and the public interest.(Commentary)
Author: John M. Balbus
Publication:Environmental Health Perspectives (Magazine/Journal)
Date: July 1, 2005
Publisher: National Institute of Environmental Health Sciences
Volume: 113 Issue: 7 Page: 818(5)

Distributed by Thomson Gale.
Price: $5.95 [Notify me when price goes down.]

Toxicogenomics is a discipline that combines expertise in toxicology, genetics, molecular biology, and environmental health to help understand the response of living organisms to stressful environments. The National Research Council convened a workshop to discuss how toxicogenomic data could be applied to improve risk assessments, particularly cancer risk from environmental exposure to chemicals. Risk assessments serve as the basis of many public-health decisions in environmental, occupational, and consumer protection from chemicals. The workshop provided a forum for communities of experts, including those working in "-omics" and those in the policy arena, to discuss where their fields intersect, and how toxicogenomics could address critical knowledge gaps in risk assessments..
Price: $6.99 [Notify me when price goes down.]

This digital document is a journal article from Science of the Total Environment, The, published by Elsevier in 2006. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
There is strong epidemiological evidence of association between PM"1"0 (particulate matter with an aerodynamic diameter less than or equal to 10 @mm) and adverse health outcomes including death and increased hospital admissions for cardiopulmonary conditions. Ambient PM"1"0 surrogates such as diesel exhaust particles (DEP), a common component of UK PM"1"0", have been shown to induce lung inflammation in both humans and rodents. To date, few studies have reported on the toxicological response of UK PM"1"0 in experimental animals. This study examines the pulmonary toxicological responses in male Sprague Dawley rats following the intratracheal instillation of Cardiff urban PM"1"0. A mild but significant change in lung permeability was observed in the lung post-instillation of a high (10 mg) dose of the whole PM"1"0 as adjudged by increases in lung to body weight ratio and total acellular lavage protein. Such effects were less marked following instillation of a water-soluble fraction (80% of the total mass) but histological examination showed that lung capillaries were swollen in size with this treatment. In conclusion, conventional toxicological, histological and toxicogenomic studies have indicated that Cardiff PM"1"0 exhibits low bioreactivity in the form of mild permeability changes. Differential gene expression was observed when the lung was treated with whole PM"1"0, containing durable particles, in comparison with the water-soluble fraction of PM"1"0 that was devoid of particles. Such changes were linked to different histopathological events within the lung. .
Price: $10.95 [Notify me when price goes down.]