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Preventing Toxic Tangles: Tea Catechins Inhibit Amyloid Protein Aggregation: Their Beneficial Effects in Huntington\\\'s and Parkinson\\\'s Disease Models
A common feature of numerous neurodegenerative disorders such as Parkinson\'s and Huntington\'s disease is the abnormal accumulation of aggregated proteins in distinct regions of the brain. Here, the author demonstrates that (-)- Epigallocatechin gallate (EGCG), a catechin present in green tea, is a potent inhibitor of this pathological process. EGCG prevents the aggregation of two different proteins by stabilizing an oligomeric conformation, leading aggregation-prone proteins on an alternative folding pathway in the misfolding cascade. This effect could be mediated by direct interaction between EGCG and proteins in an unfolded, \open\" conformation. EGCG also reduces the toxicity caused by misfolded proteins in cell culture model systems suggesting that the oligomeric protein species formed in the presence of the compound are not toxic to living cells. EGCG might therefore represent a chemical chaperone that can modulate misfolding and toxicity of proteins associated with neurodegenerative diseases and could provide the basis for the development of a novel pharmacotherapy for these fatal disorders.".
Price: $106.03
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Overcoming Assumptions that Inhibit Spiritual Development : A Lecture Delivered Before a Live Audience, Plus Teaching Stories and Narratives
A lecture by Idries Shah delivered before a live audience, plus teaching stories and narratives selected from Tales of the Dervishes This lecture, delivered in 1976, was previously entitled A Psychology of the East. Shah addresses the nature of assumptions, those that inhibit understanding and those that might be useful at certain stages of study but need to be set aside by the student at a later time in order to progress. This requires a flexibility of approach that is not customary in the West, one cultivated by study and exposure to Sufi ideas. A very humorous and lively lecture, full of stories and anecdotes. Among the other topics Shah addresses are the difference between emotionality and spirituality, the danger of looking for easy answers, and the way in which the paths of East and West are converging. This set includes a recording of teaching stories and narratives, selected and read by members of The London College of Storytellers, from Shah’s best-selling work, Tales of the Dervishes..
Price: $14.86
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Alcohol and the ability to inhibit behavior in men and women.: An article from: Journal of Studies on Alcohol
This digital document is an article from Journal of Studies on Alcohol, published by Alcohol Research Documentation, Inc. on November 1, 1997. The length of the article is 4776 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. From the supplier: Moderate doses of alcohol may impair the cognitive ability to withhold a response, while not affecting the response time. Three groups of 16 people were given either alcohol, placebo, or no treatment. Reaction times to a computerized go signal and inhibitory response times to the sounding of a stop signal were determined before grouping and after treatment. Participants in the alcohol group showed fewer inhibitions to the stop signal than those in the placebo or no-treatment groups, while overall reaction times were not affected. These results may explain the disinhibiting affect consuming alcohol can sometimes produce. Citation DetailsTitle: Alcohol and the ability to inhibit behavior in men and women. Author: L.E. Mulvhill Publication:Journal of Studies on Alcohol (Refereed) Date: November 1, 1997 Publisher: Alcohol Research Documentation, Inc. Volume: v58 Issue: n6 Page: p600(6) Distributed by Thomson Gale.
Price: $5.95
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Dried plum may inhibit microbial growth in meat.: An article from: Microbial Update International
This digital document is an article from Microbial Update International, published by Food Technology Intelligence, Inc. on December 1, 2002. The length of the article is 758 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation DetailsTitle: Dried plum may inhibit microbial growth in meat. Publication:Microbial Update International (Newsletter) Date: December 1, 2002 Publisher: Food Technology Intelligence, Inc. Volume: 8 Issue: 4 Page: NA Distributed by Thomson Gale.
Price: $5.95
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KENYA CAN'T COVER ALL THE BASES.(... budget shortfalls inhibit government policy): An article from: Market Africa Mid-East
This digital document is an article from Market Africa Mid-East, published by Media Contact Resources, Inc. on September 1, 2003. The length of the article is 556 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser. Citation DetailsTitle: KENYA CAN'T COVER ALL THE BASES.(... budget shortfalls inhibit government policy) Publication:Market Africa Mid-East (Newsletter) Date: September 1, 2003 Publisher: Media Contact Resources, Inc. Volume: 8 Issue: 6 Page: NA Distributed by Thomson Gale.
Price: $5.95
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