Books about Mitochondrial from Amazon.com

If it weren't for mitochondria, scientists argue, we'd all still be single-celled bacteria Indeed, these tiny structures inside our cells are important beyond imagining Without mitochondria, we would have no cell suicide, no sculpting of embryonic shape, no sexes, no menopause, no aging.
In this fascinating and thought-provoking book, Nick Lane brings together the latest research in this exciting field to show how our growing insight into mitochondria has shed light on how complex life evolved, why sex arose (why don't we just bud?), and why we age and die. These findings are of fundamental importance, both in understanding life on Earth, but also in controlling our own illnesses, and delaying our degeneration and death. Readers learn that two billion years ago, mitochondria were probably bacteria living independent lives and that their capture within larger cells was a turning point in the evolution of life, enabling the development of complex organisms. Lane describes how mitochondria have their own DNA and that its genes mutate much faster than those in the nucleus. This high mutation rate lies behind our aging and certain congenital diseases. The latest research suggests that mitochondria play a key role in degenerative diseases such as cancer. We also discover that mitochondrial DNA is passed down almost exclusively via the female line. That's why it has been used by some researchers to trace human ancestry daughter-to-mother, to "Mitochondrial Eve," giving us vital information about our evolutionary history.
Written by Nick Lane, a rising star in popular science, Power, Sex, Suicide is the first book for general readers on the nature and function of these tiny, yet fascinating structures..
Price: $8.30 [Notify me when price goes down.]

This book is the eagerly awaited second edition of the best-selling Mitochondria, a book widely acknowledged as the first modern, truly comprehensive authored work on the important, scientifically fundamental topic of the cellular organelles known as mitochondria.

This new edition brings readers completely up to date on the many significant findings that have occurred in the eight years since the book was first published. As in that seminal first edition, the second edition tackles the biochemistry, genetics, and pathology of mitochondria in different organisms. The new edition provides thorough updates of all literature concerning this vital organelle, its functions, ongoing research surrounding it, and its importance vis-à-vis a broad range of issues in cellular and molecular biology. The book includes detailed descriptions of current and developing technologies around mitochondrial research and discovery, and highlights subjects that are growing, such as the use of proteomics.

Praise for the first edition:

"... very valuable… I doubt that anyone could have done better."
—JOURNAL AMERICAN AGING ASSOCIATION

"... it is up-to-date, remarkably comprehensive yet concise and contains something for everyone... a wide range of 'Cell Biologists' will find this book valuable."
—CELL BIOLOGY INTERNATIONAL

"... a broadly conceived and lively account of mitochondrial biology and biochemistry... not written to be a textbook but, because [the author] writes with such clarity and spark, and… in such an organized and complete manner... it would serve very well as a... text."
—BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

Mitochondria is an invaluable resource for all geneticists, biologists, and educators in life sciences. It is also of interest for advanced students in genetics and molecular biology..
Price: $71.98 [Notify me when price goes down.]

This is the definitive, one-stop resource on preclinical drug evaluation for potential mitochondrial toxicity, addressing the issue upfront in the drug development process. It discusses mitochondrial impairment to organs, skeletal muscle, and nervous systems and details methodologies used to assess mitochondria function. It covers both in vitro and in vivo methods for analysis and includes the latest models. This is the authoritative reference on drug-induced mitochondrial dysfunction for safety assessment professionals in the pharmaceutical industry and for pharmacologists and toxicologists in both drug and environmental health sciences..
Price: $116.00 [Notify me when price goes down.]

The Genetic Strand is the story of a writer's investigation, using DNA science, into the tale of his family's origins National Book Award winner Edward Ball has turned his probing gaze on the microcosm of the human genome, and not just any human genome -- that of his slave-holding ancestors. What is the legacy of such a family history, and can DNA say something about it?

In 2000, after a decade in New York City, Ball bought a house in Charleston, South Carolina, home to his father's family for generations, and furnished it with heirloom pieces from his relatives. In one old desk he was startled to discover a secret drawer, sealed perhaps since the Civil War, in which someone had hidden a trove of family hair, with each lock of hair labeled and dated. The strange find propelled him to investigate: what might DNA science reveal about the people -- Ball's family members, long dead -- to whom the hair had belonged? Did the hair come from white relatives, as family tradition insisted? How can genetic tests explain personal identity?

Part crime-scene investigation, part genealogical romp, The Genetic Strand is a personal odyssey into DNA and family history. The story takes the reader into forensics labs where technicians screen remains, using genetics breakthroughs like DNA fingerprinting, and into rooms where fathers nervously await paternity test results. It also summons the writer¹s entertaining and idiosyncratic family, such as Ball¹s antebellum predecessor, Aunt Betsy, who published nutty books on good Southern society; Kate Fuller, the enigmatic ancestor who may have introduced African genes into the Ball family pool; and the author¹s first cousin Catherine, very much alive, who donates a cheek swab from a mouth more attuned to sweet iced tea than DNA sampling.

Writing gracefully but pacing his story like an old-fashioned whodunit, Edward Ball tracks genes shared across generations, adding suspense and personal meaning to what the scientists and Nobel laureates tell us. A beguiling DNA tale, The Genetic Strand reaches toward a new form of writing?the genetic memoir..
Price: $3.00 [Notify me when price goes down.]

This book examines recent developments in mitochondrial medicine, pharmacology and toxicology .
Price: $135.00 [Notify me when price goes down.]

The function of the heart is highly dependent on oxidative energy that is generated in mitochondria Defects in mitochondrial structure and function can be found in association with cardiovascular diseases. Mitochondria and the Heart discusses the role that mitochondria plays in cardiovascular disease, including biogenesis and function of cardiac mitochondria during normal growth, development and aging. In addition, nonbioenergetic, biogenesis and degradation pathways are explored. Understanding these pathways and the effects that mitochondrial defects have in cardiac pathology is extremely important in establishing the diagnosis and treatment of mitochondrial-based cardiac diseases..
Price: $142.34 [Notify me when price goes down.]

Mitochondrial Medicine is a relatively new area where several disciplines from basic science to clinical medicine converge. Mitochondrial medicine deals with diseases that are related to mitochondrial dysfunction due to a number of causes from free radical damage to genetic mutation. A primary feature of mitochondrial dysfunction is impaired cellular bioenergetics.

This book is based upon extensive data gathered over 30 years of clinical and experimental research. Internationally recognized authors share their experience and state-of-the-art knowledge in various fields of their expertise such as mitochondrial cardiology, neurology, diabetology, nephrology, immunology, rheumatology, reproductive medicine, sports medicine, and chronobiology, and guide readers through the disease process, from basic biochemical mechanisms to diagnosis to therapeutic aspects.

Laboratory evaluation plays a very important role in the diagnosis of mitochondrial diseases, in addition to clinical assessment. This includes analysis of plasma/mitochondrial coenzyme Q₁₀ content, mitochondrial respiratory chain function and oxidative phosphorylation in isolated mitochondria and biopsy material, and nuclear magnetic resonance methods.

In addition to standard medical therapy to treat cardiac, CNS, and other involvements in the mitochondrial disease patients, adjunctive nutritional therapy is indicated primarily to improve mitochondrial function. Therapy include coenzyme Q₁₀, a -lipoic acid, carnitine, w -3- and w -6-PUFA, vitamins and polarized light.

Mitochondrial Medicine is dedicated to Dr. Frederick L. Crane, discoverer of Coenzyme Q₁₀ in 1957, and to the Celebration of 50^th year of Coenzyme Q₁₀ discovery.

This book is intended for general medical practitioners, for specialists specialists such as cardiologists, neurologists, and diabetologists, biochemists, nutritionists, pharmacists, and also for graduate students.

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Price: $142.62 [Notify me when price goes down.]

Mitochondrial dysfunction is increasingly being recognized as the basis of a wide variety of human diseases. Providing an authoritative update on our current knowledge of mitochondrial medicine, this text draws together world authorities from various fields to present general therapeutic strategies, as well as the treatments presently available in different specialties - thus making it essential reading for clinicians involved with the management of patients with mitochondrial diseases. A unique work, this text covers a range of specialties, including cardiology, ophthalmology, otology, nephrology, gastroenterology, hematology-oncology, and reproductive medicine, and does not focus exclusively on the more commonly known neurologic conditions. An accessible, user-friendly text, it also presents translational concepts of mitochondrial biogenesis and genetics in vignettes related to specific questions raised by the disease under discussion, rather than concentrating on basic science, which can often intimidate clinicians. This pioneering work is primarily directed to a clinical audience who are interested in the diverse and diagnostically challenging clinical presentations of mitochondrial diseases and their pathophysiology..
Price: $220.00 [Notify me when price goes down.]

Ancient DNA Typing is a comprehensive manual about the analysis of ancient and degraded DNA. It is an equally useful textbook and working tool for various disciplines such as: Anthropology, Archaeology, Forensic Medicine, Conservation Biology, Environmental Sciences and Food Engineering.
The reader benefits from a clear division of strategies, methods and applications with many interesting examples of the analysis of historic skeletal and cultural remains. The book contains a detailed protocol chapter which serves as a lab manual with the most important methods for DNA extraction, PCR and electrophoretic analysis of degraded samples. The appendix helps to set up a PCR lab specializing in ancient DNA research and answers the most frequent questions concerning technical problems in investigations of degraded DNA..
Price: $83.97 [Notify me when price goes down.]