Books about Pharmacologists from Amazon.com

Vital information for discovering and optimizing new drugs
"Understanding the data and the experimental details that support it has always been at the heart of good science and the assumption challenging process that leads from good science to drug discovery. This book helps medicinal chemists and pharmacologists to do exactly that in the realm of enzyme inhibitors."
-Paul S. Anderson, PhD
This publication provides readers with a thorough understanding of enzyme-inhibitor evaluation to assist them in their efforts to discover and optimize novel drug therapies. Key topics such as competitive, noncompetitive, and uncompetitive inhibition, slow binding, tight binding, and the use of Hill coefficients to study reaction stoichiometry are all presented. Examples of key concepts are presented with an emphasis on clinical relevance and practical applications.
Targeted to medicinal chemists and pharmacologists, Evaluation of Enzyme Inhibitors in Drug Discovery focuses on the questions that they need to address:
* What opportunities for inhibitor interactions with enzyme targets arise from consideration of the catalytic reaction mechanism?
* How are inhibitors evaluated for potency, selectivity, and mode of action?
* What are the advantages and disadvantages of specific inhibition modalities with respect to efficacy in vivo?
* What information do medicinal chemists and pharmacologists need from their biochemistry and enzymology colleagues to effectively pursue lead optimization?
Beginning with a discussion of the advantages of enzymes as targets for drug discovery, the publication then explores the reaction mechanisms of enzyme catalysis and the types of interactions that can occur between enzymes and inhibitory molecules that lend themselves to therapeutic use. Next are discussions of mechanistic issues that must be considered when designing enzyme assays for compound library screening and for lead optimization efforts. Finally, the publication delves into special forms of inhibition that are commonly encountered in drug discovery efforts, but can be easily overlooked or misinterpreted.
This publication is designed to provide students with a solid foundation in enzymology and its role in drug discovery. Medicinal chemists and pharmacologists can refer to individual chapters as specific issues arise during the course of their ongoing drug discovery efforts..
Price: $79.91 [Notify me when price goes down.]

As vacationing Ben Candidi and Rebecca Levis sail through International Waters toward Grand Bahama Island, they receive a strange welcome—a sinking cabin cruiser with a dead man at the helm. Ben knows how to patch bullet holes below the waterline and Rebecca knows how to estimate time of death. And they agree that the West End marina is the right place to bring the body. To avoid trouble, they play it dumb and treat the cocaine-smuggling marina tenants as the divers and sport fishermen they are pretending to be. Unfortunately, the mailbox corporation in Miami that owns the yacht ignores Ben's $100,000 salvage claim—and the Bahamian police won't let him move the yacht to Florida. The harder Ben and Rebecca press their claim, the more sinister West End becomes. Should they cut their losses and run? Or is it too late already?.
Price: $10.89 [Notify me when price goes down.]

The fourth novel in the Ben Candidi Series, Amazon Gold is a mystery-thriller that appeals to the intellect The story is powered by medical science, business and anthropology, and is driven by the professional challenges of a two-career couple.

There is no room for Ben Candidi (Ph.D.) in the dugout canoe that will take Rebecca Levis (M.D.) deep into the Amazon rain forest to provide medical care to the once-fierce Yanomama Indians. The freelance scientist kisses his physician soul mate goodbye and returns to Miami to complete his report — predicting how emerging technologies may speed the discovery of new drugs. Client Michael Malencik and his unnamed company are impatient and vaguely dissatisfied with Ben’s preliminary findings. His project is set back by an unannounced visit by the DEA and by fallout from an anthropology conference which he attends to take notes for Rebecca. Ben’s quick thinking foils an assassination attempt on the keynote speaker who then proves suspicious and ungrateful. Other distractions include a surprise visit from Nica Brasaro, flight attendant on the Manaus-to-Miami run.

Working hard on the technology project, Ben discovers something much more valuable than predictions. But Rebecca does not return with her expedition and her brief, infrequent satellite e-mails are becoming increasingly strange. When they stop altogether, Ben throws down his report and picks up his backpack.

Searching for Rebecca deep in the Brazilian rain forest, Ben wonders whether his most important clues may be back in Miami. In a stunning climax, Ben and Rebecca are reunited to discover astonishing truths — and to fight for their lives..
Price: $7.48 [Notify me when price goes down.]

Purposefully designed as a resource for practicing and student toxicologists, Statistics and Experimental Design for Toxicologists and Pharmacologists, Fourth Edition equips you for the regular statistical analysis of experimental data. Starting with the assumption of basic mathematical skills and knowledge, the author supplies a complete and systematic yet practical introduction to the statistical methodologists available for, and used in, the discipline. For every technique presented, a worked example from toxicology is also presented. See what's new in the Fourth Edition: · The first practical guide to performing meta analysis allowing for using the power inherent in multiple similar studies · Coverage of Bayesian analysis and data analysis in pharmacology and toxicology · Almost 200 problems with solutions · Discussion of analysis of receptor binding assays, safety pharmacology assays and other standard types conducted in pharmacology · A new chapter explaining the basics of Good Laboratory Practices (GLPs) · For those with computer skills, this edition has been enhanced with the addition of basic SAS Written specifically for toxicologists and pharmacologists, the author draws on more than 30 years of experience to provide understanding of the philosophical underpinnings for the overall structure of analysis. The book's organization fosters the ordered development of skills and yet still facilitates ease of access to information as needed. This Fourth Edition gives you the tools necessary to perform rigorous and critical analysis of experimental data and the insight to know when to use them..
Price: $39.98 [Notify me when price goes down.]

**A Tale of Mystery and Suspense from the World of Entrepreneurial Drug Development** One week before receiving his Ph.D. in pharmacology, Ben Candidi is offered a high-paying, four-day consulting job. Ben will consult for Brian Broadmoore, M.D., a Boston biomedical venture capitalist who has come to Miami on business. Dr. Broadmoore has bought an option to purchase BIOTECH, a Miami-based biotechnology company. BIOTECH has patents on three compounds from sponge extracts that show promise as a cure for cancer.

BIOTECH's price is $20 million. Dr. Broadmoore's option to purchase will run out in four days. He will pay Ben $24,000 to visit BIOTECH and check out their scientific claims. Ben goes to work. After auditing BIOTECH's records for one day, he confirms dramatic tumor shrinkage in animals. And the patents check out. Everything checks out except for BIOTECH's key personnel. The president is a gruff-mannered construction tycoon. The head scientist dresses like a f! ashion model and has an attitude to match. And BIOTECH's inventor is as helpful as a bad guy in a karate movie.

On the second day of the job, Ben wonders why Dr. Broadmoore hired him on such short notice. And what happened to Ben's predecessor? And why won't Dr. Broadmoore give him a straight answer? On the third day, Ben is caught in a web of murder and high-stakes intrigue. Dirk Wyle describes a high-tech, multi-player gamble to transform a $50,000 discovery into a $200-million stock offering. He takes the reader on an exciting treasure-hunt in uncharted territory between the lab bench, clinic, patent office, and executive suite..
Price: $2.00 [Notify me when price goes down.]

This is the third in the Ben Candidi Mystery Series by biomedical scientist Dirk Wyle. From the back cover: When Rebecca said it was a great career opportunity, Ben had to agree. But with Rebecca in the middle of her training program, Ben's opportunity will mean separation for six months. Ben Candidi, Ph.D., leaves his physician soulmate in Washington DC and returns to Miami's Bryan Medical School to take over a dead scientist's laboratory and two-year grant. And when he is offered $20,000 to write the biography prescribed in eccentric Dr. Peter Peterson's will, Ben accepts that opportunity, too. Collecting humorous anecdotes about the talkative old bachelor and WW-II hero is simple, but making sense of his after-hours "crusades for science and reason" is much harder. Dr. Peterson made many enemies when he spoke out on public corruption, the right to die, abortion, animal experimentation, human cloning and meat irradiation. And how should Ben deal with rumors that Dr. Peterson had falsified his lab data on dietary supplements? Should Ben heed anonymous warnings to stop looking for substance in Dr. Peterson's "crusades"? Was last night's burglary just another random act of Miami violence? And what should he tell Rebecca, the next time she calls from Washington? Can he write off the poorly-documented crusades as the delusions of an attention-starved old man? Or was it something other than a heart attack that left Old Pete floating in the canal by Bryan Medical School?.
Price: $7.48 [Notify me when price goes down.]

A biography of the woman who used her understanding of chemistry to help develop medicines and who devoted her life to helping others..
Price: $31.95 [Notify me when price goes down.]