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This digital document is an article from Biotech Business, published by Worldwide Videotex on March 1, 2002. The length of the article is 428 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.

Citation Details
Title: UNIVERSITIES COMMERCIALIZE TECHNOLOGY TO RE-SENSITIZE BACTERIA.
Publication:Biotech Business (Newsletter)
Date: March 1, 2002
Publisher: Worldwide Videotex
Volume: 15 Issue: 3 Page: NA

Distributed by Thomson Gale.
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This digital document is a journal article from Behaviour Research and Therapy, published by Elsevier in . The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
Prominent models of fear focus on the role of cognition in the development and maintenance of maladaptive responses. Little research, however, has evaluated the impact of cognition on distress reduction. The current study uses an experimental design to examine the effect of different types of imagery (moving harm, static harm, and safety) on reduction of distress associated with a contaminating stimulus in a normal university sample. Results indicate that use of moving harm imagery sensitizes distress during a 30-min exposure, whereas static harm and safety imagery reduce distress. These findings demonstrate that cognitive factors can moderate affective response during exposure. Clinical implications for the treatment of anxiety disorders are discussed. .
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This digital document is a journal article from DNA Repair, published by Elsevier in 2004. The article is delivered in HTML format and is available in your Amazon.com Media Library immediately after purchase. You can view it with any web browser.

Description:
A critical pre-cytotoxic and -apoptotic DNA lesion induced by methylating carcinogens and chemotherapeutic drugs is O^6-methylguanine (O^6MeG). The mechanism by which O^6MeG causes cell death via apoptosis is only partially understood. The current model ascribes a role to DNA replication and mismatch repair, which converts O^6MeG into a critical distal lesion (presumably a DNA double-strand break) that is finally responsible for genotoxicity and apoptosis. Here we analysed whether the PI3-like kinase ATM is involved in this process. ATM is a major player in recognizing and signaling DNA breaks, but most reports are limited to ionizing radiation. Comparing mouse ATM knockout fibroblasts (ATM-/-) with the corresponding wild-type (ATM+/+) we show that ATM-/- cells are hypersensitive to the cytotoxic and apoptosis-inducing effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Inhibition of O^6-methylguanine-DNA methyltransferase (MGMT) activity by O^6-benzylguanine enhanced cell killing whereas the increase of MGMT activity by transfection with an expression vector provoked MNNG resistance. This was more pronounced in ATM-/- than in ATM+/+ cells, suggesting that O^6MeG is responsible, at least in part, for increased MNNG sensitivity of ATM-/- cells. Cytogenetic studies showed that MNNG-induced sister-chromatid exchange frequencies were the same in ATM-/- and ATM+/+ cells in the first mitoses following treatment, but higher in ATM-/- cells than in the wild-type in the second post-treatment mitoses, when MGMT was depleted. Also, a significant higher frequency of MNNG-induced chromosomal aberrations was observed in ATM-/- than in ATM+/+ cells when analysed at a late recovery time, which is consistent with O^6MeG being the inducing lesion. In summary, we conclude that ATM is not only involved in resistance to ionizing radiation but also to methylating agents, playing a role in the repair of secondary DNA damage generated from O^6MeG lesions. The data also show that ATM is not required for activating the apoptotic pathway in response to O^6MeG since ATM-/- cells are able to undergo apoptosis with high frequency. .
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The Yoga of Creativity explores a relationship between the physical and spiritual practice of creativity Fifty diverse individual and partner exercises provide a perfect resource for your own spiritual and creative exploration. Among the exercises described in the book are: drawing a mandala, writing poetry, using clay to sculpt your partner’s body language, and creating a recipe from sense memory. Understanding the implications and applications of sensory awareness can give you a repertoire of expanded options in manifesting truthful and fulfilling creative work..
Price: $12.93 [Notify me when price goes down.]

This digital document is an article from Long-Term Living, published by Vendome Group LLC on June 1, 2008. The length of the article is 3063 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available immediately after purchase. You can view it with any web browser.

Citation Details
Title: Tuning in to the 'sound' environment: improve quality of life, sensitize staff to hearing-impaired residents.(ENVIRONMENT FOR AGING)
Author: Susan E. Mazer
Publication:Long-Term Living (Magazine/Journal)
Date: June 1, 2008
Publisher: Vendome Group LLC
Volume: 57 Issue: 6 Page: 30(6)

Distributed by Gale, a part of Cengage Learning.
Price: $9.95 [Notify me when price goes down.]