This
digital document is an
article from
Journal of
Studies on Alcohol,
published by
Alcohol Research Documentation, Inc. on January 1, 2000. The length of the article is 6681 words. The page length shown above is based on a typical 300-word page. The article is delivered in HTML format and is available in your Amazon.com Digital Locker immediately after purchase. You can view it with any web browser.
From the author: Objective: This study examined the hypothesis that a decreased reaction to alcohol and a deficit in prepulse inhibition (PPI) of the startle reflex are characteristics of male offspring of alcoholics without comorbid anxiety disorder. Method: Male offspring (N = 51) with a parental history of (1) alcoholism only, (2) anxiety disorder only, (3) alcoholism and anxiety disorder, and (4) no psychiatric disorder participated in an experiment examining the effects of alcohol on the acoustic startle reflex and on PPI. The experiment was carried out in two sessions in which subjects received an alcoholic beverage and placebo beverage on alternate days. Results: The magnitude of startle was reduced by alcohol in each group. However, the degree of reduction was less in the offspring of alcoholics only compared to the other groups. In addition, PPI was reduced in the offspring of alcoholics only compared to the offspring of parents with no psychiatric disorder. Conclusions: A reduced reactivity to the effect of alcohol and a deficit in PPI might constitute vulnerability markers for alcoholism, but only in offspring of alcoholics without comorbid anxiety disorder. (J. Stud. Alcohol 61: 46-54, 2000)
Citation DetailsTitle: Effects of Alcohol on Baseline Startle and Prepulse Inhibition in Young Men at Risk for Alcoholism and/or Anxiety Disorders(*).
Author: Christian Grillon
Publication:Journal of Studies on Alcohol (Refereed)
Date: January 1, 2000
Publisher: Alcohol Research Documentation, Inc.
Volume: 61
Issue: 1
Page: 46
Distributed by Thomson Gale.
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